RUNX1 and amyotrophic lateral sclerosis: RUNX1 expression was found to be significantly increased in samples of muscle dystrophies, including mouse models of Duchenne muscular dystrophy (DMD) [8] and amyotrophic lateral sclerosis (ALS) [9], myopathy patients (including EDMD, DMD, AQM [10]) and in cardiotoxin (CTX)-treated muscle [11].