The genes only present and up-regulated in CD34+ cells of JAK2V617F positive PMF origin were: TPSG1, LRRC27, MAPT, while down-regulated were: SPSB1, DLX4, TSPAN4, and GNL1. The genes solely up-regulated in CD34+ cells of JAK2V617F negative ET/PMF origin were CEP95, PTBP2, while down-regulated were CNOT2 and FN1 (Fig 1). This evidence concerns the gene TSPAN4 and essential thrombocythemia.