The following genes had increased expression both at protein and mRNA levels in JAK2 positive MPN subjects: ANXA1 in ET and PMF; CAI, charged multivesicular body protein 5 (CHMP5), ficolin 1 (FCN1), major vault protein (MVP) in PV; copine III (CPNE3), formin binding protein 1 (FNBP1), S100A4 in PMF; as well as in JAK2 negative MPN subjects: tropomyosin 3 (TPM3), CAT, ACTR2, and LTA4H (Table 4). The gene discussed is CPNE3; the disease is myeloproliferative neoplasm.