HMGB1 and acute respiratory distress syndrome: The ability of baseline arterial levels of esRAGE, HMGB1, S100A12 and AGEs to discriminate between nonfocal and focal ARDS was also determined; AUC were 0.65 (95% CI, 0.39–0.91), 0.63 (95% CI, 0.38–0.88), 0.49 (95% CI, 0.24–0.74), 0.48 (95% CI, 0.23–0.74) for baseline arterial HMGB1, S100A12, AGEs and esRAGE, respectively (Fig 3).