HMGB1 and acute respiratory distress syndrome: Despite multivariate analysis found colinearity between the 5 markers measured in arterial blood from ARDS patients at baseline, sRAGE, esRAGE, S100A12 and AGEs were associated with PaO2/FiO2 (P = 0.006, 0.012, 0.002 and 0.006, respectively), but HMGB1 was not (P = 0.3).