HMGB1 and acute respiratory distress syndrome: The ability of baseline arterial levels of other markers to discriminate between patients with or without ARDS was also determined; AUC were 0.94 (95% CI, 0.87–1), 0.73 (95% CI, 0.59–0.88), 0.65 (95% CI, 0.49–0.81), 0.65 (95% CI, 0.49–0.81) for baseline arterial S100A12, AGEs, HMGB1 and esRAGE, respectively (Fig 2).