WDTC1 and stroke disorder: Aspirin had the strongest prophylactic effect against non-fatal stroke compared with placebo (RR: 0.73; 95% CrI: 0.55–0.97, NNT = 292) and at a class level, both ADP antagonists (RR: 0.70; 95% CrI: 0.51–0.95, NNT = 268) and aspirin (RR: 0.74; 95% CrI: 0.58–0.95, NNT = 313) offered a significant protection against stroke (Figs 5 and 7).