PRKN and Parkinson disease: Our CNV analysis failed to detect any gene dosage alterations in PD related genes apart from PARKIN. A homozygous loss that affected exon 7 was detected in affected members in one family (S4D Fig and S3 Table), and a homozygous deletion of exons 3 and 4 was confirmed in a sporadic case (S3 Table), deletions affecting these exons were previously reported [56, 57].