PTK2 and colonic neoplasm: In the vast majority of samples, FAK/p-GSK3α/βY279/Y216/β-catenin (19 of 26 samples) and PYK2/p-GSK3α/βY279/Y216/β-catenin (18 out of 26 samples) were regulated in the same way, supporting that they are related events in the development of colonic cancer (Figure 6C).