To determine whether the positive correlations between the levels of FAK, PYK2, p-GSK3α/βY279/Y216 and β-catenin are commonly seen in human CRC tissues, we performed IHC for these markers on CRC tissue microarray containing 34 cases of colorectal adenocarcinoma with 26 matched and 8 unmatched adjacent normal tissues. Here, PTK2B is linked to colorectal adenocarcinoma.