In CRC cells predominantly expressing either FAK (HT-29 cells) or PYK2 (SW480 cells), KD of FAK or PYK2 alone was sufficient to reduce the levels of phosphorylated GSK3αY279 and GSK3βY216 and total β-catenin (Figure 3D,E). The gene discussed is PTK2; the disease is colorectal carcinoma.