We therefore analyzed more than 140,000 cancer sample entries from public cancer genomic databases (COSMIC, cBioPortal and ICGC) for point mutations in the orientation-switch III region of HRAS, NRAS, and KRAS genes; specifically, in the β2-β3-loop and helix α5 (switch III), as well as the orientation stabilizing elements, the helix α4 and the hvr. The gene discussed is NRAS; the disease is cancer.