Local sprouting of cones seen in the outer nuclear layer and enlarged pedicles in the outer plexiform layer (10, also this study) suggested that cone photoreceptors of Cav1.4-IT retinas are in the process of degeneration; similar to Cav1.4 deficient retinas40 and, although less prominent, human retinitis pigmentosa retinas.37 This evidence concerns the gene CACNA1F and retinitis pigmentosa.