Our results showed that levels of miRNA/mRNA pairs: miR-451/TLR4, miR-4793-3p/TLR4, miR-132/HBEGF, miR-1290/THBS1, miR-132/CD44, miR-223/ICAM1, miR-132/MMP9, miR-146-3p/GNA11 and miR-146-3p/MYLK were significantly correlated in an inverse manner in NEC tissues, whereas miR-410/FLT-1 was directly correlated (Fig 2). The gene discussed is HBEGF; the disease is necrotizing enterocolitis.