Through a bioinformatics approach, we identified a variant, rs17168525, located in the let-7/miR-98 target site in the 3′-UTR of myotrophin. In the present study, we aimed to investigate whether the rs17168525 can modify the efficiency of let-7/miR-98 binding to myotrophin and then further contribute to the genetic susceptibility to cardiac hypertrophy. This evidence concerns the gene MTPN and cardiac hypertrophy.