CNTNAP2 and autism: Here we provide an extensive behavioral characterization and analysis of two mouse models of autism, the 16p11.2 heterozygous null (16p11.2 df/+) and Cntnap2 homozygous null (Cntnap2 -/-) mice, chosen because of their strong construct validity and the robust human genetic evidence that implicate these loci in autism [16–21].