TCF21 and obesity due to melanocortin 4 receptor deficiency: The ratio of expression level of TBX1 to TCF21 (TBX1/TCF21) in obesity group was significantly greater than those in normal and T2DM groups (P < 0.01), suggesting that the lipid metabolic activity of visceral adipose tissue in obesity individuals was lower than those in normal and T2DM individuals.