The result showed that five candidate genes, including T-box protein 1 (TBX1), transcription factor 21 (TCF21), adiponectin (APN), tumor necrosis factor-alpha (TNF-α), and monocyte chemotactic protein 1 (MCP-1), were all expressed in the visceral adipose tissue of normal, obesity, and T2DM individuals in Uygur population. This evidence concerns the gene TCF21 and obesity due to melanocortin 4 receptor deficiency.