The TBX1 and TCF21 expression levels in the obesity group were significantly higher than those of normal and T2DM groups (P < 0.01); and the TBX1 and TCF21 expression levels in the T2DM group were significantly lower than those of normal and obesity groups (Figure 1, P < 0.01). The gene discussed is TCF21; the disease is obesity due to melanocortin 4 receptor deficiency.