The ratio of expression level of TBX1 to TCF21 (TBX1/TCF21) in obesity group was significantly greater than those in normal and T2DM groups (P < 0.01), suggesting that the lipid metabolic activity of visceral adipose tissue in obesity individuals was lower than those in normal and T2DM individuals. Here, TBX1 is linked to obesity due to melanocortin 4 receptor deficiency.