In the CACTI trial, Maahs et al. reported negative correlations between adiponectin levels and male sex, central adiposity, SBP, DBP, daily insulin dose, HbA1c, fibrinogen, albumin excretion rate, and TG levels; positive correlations were noted with type 1 diabetes, HDL-C, and homocysteine [59]. This evidence concerns the gene INS and type 1 diabetes mellitus.