Mathematical models estimate that, adding the HLA and VNTR contribution, up to 60% of the total genetic component of T1D is obtained [19]. VNTR polymorphisms located in the insulin promoter, 596 bp upstream of the insulin start codon, consist of a highly polymorphic tandem repeat sequence ACAGGGGTGTGGGG (14 pb) whose variants are grouped into three classes of alleles according to their length [20, 21]. The gene discussed is INS; the disease is type 1 diabetes mellitus.