TCF7L2 and obesity due to melanocortin 4 receptor deficiency: In conclusion, our results show that the Pro12Ala mutation in the PPAR-γ2 gene is unlikely to serve as clinically useful predictor of T2DM and/or obesity in Emiratis. TCF7L2 variation may be a risk factor for the occurrence of T2DM in Arab populations, but this association relies on the obesity status.