TCF7L2 variant rs7903146 a C-to-T (genomic position: 114748339) substitution in intron 3 and PPAR-γ2 Pro12Ala have been most extensively studied in all major ethnic groups and were found to be more consistently associated with the risk of developing T2DM in most of populations, such as Asians, Africans, and Caucasians [12, 13]. This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.