ROS-associated base damage can be repaired by the BER pathway, which is initiated by many damage-specific glycosylases that cleave the glycosylic bond between the damaged base and the sugar phosphate backbone [8]. MUTYH, which removes adenine paired with 8-oxo-G, is important in suppressing G·C to T·A transversions and in preventing CRC in people and mice. This evidence concerns the gene MUTYH and colorectal carcinoma.