Indeed, there was no increase in S100A8 level in the serum of patients with NASH compared to control; however, the levels of S100A9 and S100A8/A9 were significantly elevated in patients with NASH with a P value < 0.01 (P = 0.0168 and P = 0.0001, resp). Here, S100A8 is linked to metabolic dysfunction-associated steatohepatitis.