Furthermore, SIRT1 mediated the role of resveratrol in regulating expression of cell cycle regulatory molecules and arresting PDGF-BB treated HPASMCs in G0/G1 phase, which contributed to the attenuation of pulmonary arterial remodeling and the alleviation of pulmonary arterial hypertension in MCT-treated rats. The gene discussed is SIRT1; the disease is pulmonary arterial hypertension.