Among JAS patients with HLA-B∗2704, HLA-B∗2705, and HLA-B∗2715, there were no significant difference in male ratio, positive family history, peripheral arthritis, enthesitis, hip arthritis, iridocyclitis, and indicators, for example, BASDAI, BASFI, ESR, and CRP, which showed that the pathogenesis of different subtypes might be similar. The gene discussed is CRP; the disease is enthesitis.