Since EGF receptor (EGFR) stimulation triggers signaling cascades controlling cellular proliferation, migration, differentiation, and survival, and EGFR overexpression has been associated with poor prognosis in several types of epithelial cancers, such as lung, head and neck, colorectal, and breast cancer [54], EGFR-SAM68 signaling could be targeted to attenuate the oncogenic features of cancer cells. The gene discussed is KHDRBS1; the disease is cancer.