In addition to CD44, changes in alternative splicing of other transcripts, including Caspase 2 (CASP2) [94], BCL-2 [90], the p53 negative modulators MDM2 and MDM4 [95], and Cyclin D1 (CCND1), have been observed in cancer cells after treatment with chemotherapy drugs [96, 97]. This evidence concerns the gene CASP2 and cancer.