Notably, CCND1 pre-mRNA was also identified as a novel alternative splicing target of SAM68 [74]. CCND1 is a protooncogene that is frequently deregulated in several human cancers through different mechanisms, such as chromosomal translocations, amplification of the CCND1 locus, and intragenic mutations [97–99]. The gene discussed is KHDRBS1; the disease is cancer.