Recently, a long noncoding RNA (named INXS) has been described as a novel mediator of SAM68-dependent regulation of BCL-X splicing. INXS is transcribed from the antisense genomic strand of BCL-X gene and is downregulated in various tumor cell lines and in kidney tumor tissues, whereas its expression is induced by treatments that trigger apoptosis [136]. INXS interacts with SAM68 and favors its splicing activity, thus increasing the levels of BCL-X(s) isoform and enhancing apoptosis [136]. This evidence concerns the gene KHDRBS1 and neoplasm.