The CD44 gene represents an interesting example of SAM68-mediated coupling between signal transduction cascades and alternative splicing. CD44 pre-mRNA is affected by complex alternative splicing events occurring in 10 adjacent exons (v1–v10) to produce multifunctional transmembrane glycoprotein isoforms implicated in cell-cell and cell-matrix adhesion, migration, and invasion [77] and with crucial roles in cancer progression and metastasis [78]. This evidence concerns the gene KHDRBS1 and cancer.