To summarize the PNPLA3 I148M variant is a robust genetic determinant of hepatic steatosis triggered by a number of environmental factors [9, 85] and the PNPLA3 associated steatohepatitis (PASH) may be mediated by a direct effect on hepatocyte and on hepatic stellate cells [86]. This evidence concerns the gene PNPLA3 and Pyoderma gangrenosum-acne-suppurative hidradenitis syndrome.