SLC27A5 and metabolic dysfunction-associated steatotic liver disease: In the liver FATP2 and FATP5 are predominantly expressed [112]. FATP5 encodes a multifunctional protein which increases the hepatic FFA uptake and activates very long-chain fatty acids and has bile-CoA ligase activity [113, 114]. FATP5 silencing reversed diet-induced NAFLD and improved hyperglycemia in mice [115].