SAFB and cancer: Another interesting observation from the iCLIP dataset revealed significant SAFB1 binding sites to metastasis associated lung adenocarcinoma transcript 1 (MALAT-1). MALAT-1 is a highly conserved long ncRNA enriched in nuclear speckles that regulates alternative splicing by modulating splicing factor phosphorylation [18]. MALAT-1 is overexpressed in many different cancers including breast and is considered an oncogenic long ncRNA [19, 20].