RORC and rheumatoid arthritis: Given that previous study reported that IL-17 and MMP-3 also participated in osteoclastogenesis and played a crucial role in inflammation and bone erosion in RA patients and in CIA mice [10, 13, 14], we next evaluated potential effect of T-614 on the production of IL-17 and its transcriptional factor RORc, as well as MMP-3 mRNA expression in IL-6-induced RASFs (Figure 4).