Jakobsen et al. performed a global profile of gene expression in palatal tissue from patients with nonsyndromic forms of cleft palate and cleft lip and palate, identifying genes such as OPN (encoding for osteopontin) and CCR4 (encoding for chemokine receptor 4) that were differentially expressed between these groups suggesting a role in palatal development [71]. The gene discussed is SPP1; the disease is cleft palate.