Microglial pattern recognition receptors also include integrin CD11b/CD18 (MAC1, macrophage antigen complex-1, also known as complement receptor 3, CR3) that mediates LPS-induced production of superoxide and whose expression has been found to be elevated in the brains of post mortem Alzheimer's disease patients [62, 63]. This evidence concerns the gene ITGB2 and Alzheimer disease.