The Bbs10−/− mice recapitulated most clinical features of the human condition, ranging from early-onset obesity, retinal degeneration and renal dysfunction whereas the Bbs10 fl/fl; Cadh16Cre+/− mice show neither detectable renal defect at 3 months nor any other noticeable manifestations. The gene discussed is BBS10; the disease is obesity due to melanocortin 4 receptor deficiency.