Interestingly, it has been demonstrated that mouse MSCs are able to ameliorate the emphysematous changes and reduce destruction in elastase-induced emphysema model through upregulation of hepatocyte growth factor (HGF), epithelial growth factor (EGF), and secretory leukocyte protease inhibitor (SLPI) in the lung [75]. This evidence concerns the gene SLPI and pulmonary emphysema.