POU5F1 and cancer: HIFs are considered as crucial regulators of the stem cell phenotype through Notch signaling pathways and induce the expression of stem cell markers, such as Oct4 [65], and induce pluripotent stem cell (iPSC) factors, Oct4, Nanog, Sox2, Klf4, and c-Myc, in many cancer cell types, including prostate, brain, kidney, cervix, lung, colon, liver, and breast tumors [76].