For instance, insulin-like growth factor binding protein 3 (IGBP3) can suppress ROS-mediated cytotoxicity by novel insulin-like growth factor (IGF), independent antioxidant activity, thereby increasing CD44H cells in esophageal squamous cell carcinoma (ESCC) and facilitating ESCC cell adaptation and survival under hypoxia [87]. The gene discussed is IGFBP3; the disease is esophageal squamous cell carcinoma.