TGFB1 and neoplasm: Other immune cells such as dendritic cells have also been reported to be compromised by the tolerogenic tumor microenvironment: Being exposed to factors such as being secreted by the tumor microenvironment, dendritic cell differentiation can be arrested in an immature state and are then enabled to induce regulatory T cells by the secretion of IL-10 and TGF-β, thus further impairing the antitumor response.