The level of IL-1β was also very low at baseline (0.71 ± 0.1 pg/mg protein, sham group), slightly increased 2 h after the hypoxia-ischemia insult (3.15 ± 0.52 pg/mg protein, HI group), and markedly elevated 6 h after the hypoxia-ischemia insult (25.97 ± 3.89 pg/mg protein, HI group). The gene discussed is IL1B; the disease is ischemia.