We scanned the interacting networks to find key TFs that could be crucial in regulating gene expression during development, differentiation and function of immune cells and/or tumor cell metastases identified AIF1, IKZF1, MNDA, SAMSN1, EOMES, GFI1 and KLHDC7B as significant TF-hubs within Set 1/Set 1-s gene networks in the six conserved tumor types (Supplementary Dataset 4; Supplementary Table S2). This evidence concerns the gene KLHDC7B and neoplasm.