In case of COAD patients, 18 Set 1 genes were identified as risk genes, 5 of which viz. PLEK, CLEC4A, LCP2, ITK and CD53 were classifiers (Supplementary Dataset 7; Supplementary Fig. S2; Supplementary-Dataset 7; Supplementary Table S1; p ≤ 0.01). The gene discussed is CD53; the disease is colon adenocarcinoma.