To confirm that regulation of immunomodulation and metastasis by master regulators AIF1 and PRRX1 were not specific to the TCGA datasets, we independently validated gene interactions regulated by Set 1/Set 1-s and Set 2 for six cancers in in other datasets of six cancers (Supplementary Dataset 3; Supplementary Table 1). The gene discussed is PRRX1; the disease is cancer.