To evaluate this, we further identified six Set 1/Set 1-s common risk factors in COAD, OVCA, READ, GBM and LUAD (PLEK, LCP2, CD53, MNDA, NCF2, CYBB; p < 0.05; Fig. 4a-i; OVCA was an outlier and failed to demonstrate any commonality in this set of genes). This evidence concerns the gene CD53 and glioblastoma.