The pre-treatment MIF urinary excretion value in PGN positively correlated with interstitium volume, glomerulosclerosis grade and serum creatinine concentration: ρ = 0.28, P = 0.03; ρ = 0.3, P = 0.037; ρ = 0.34, P = 0.026; respectively. The gene discussed is MIF; the disease is glomerulosclerosis.