A missense variant in ALPL (rs34605986 [A], MAF=15.21%, NP_000469.3:p.Val522Ala) that correlates with rs1256328 (r2=0.73) also associates with kidney stones (OR=1.19, P=8.9 × 10−8) (Supplementary Table 1). This evidence concerns the gene ALPL and nephrolithiasis.