A GWAS in the Japanese population involving 904 cases and 7,471 controls reported three loci associated with kidney stones following replication in additional cases and controls, RGS14-SLC34A1, encoding regulator of G-protein signalling 14 and the Na/Pi co-transporter solute carrier family 34 member 1, on 5q35.3 (rs11746443[A], OR=1.19, P=8.5 × 10−2), INMT-FAM188B-AQP1, a locus including the gene encoding aquaporin 1, on 7p14.3 (rs1000597[C], OR=1.22, P=2.2 × 10−14), and DGKH, encoding diacylglycerol kinase eta, on 13q14.1 (rs4142110[C], OR=1.14, P=4.6 × 10−9)14. This evidence concerns the gene AQP1 and nephrolithiasis.