The strongest signal associating with kidney stones is a two base pair deletion in intron 1 of CLDN14 rs199565725[delAC] (MAF=23.68%, OR=0.81, P=4.7 × 10−13) (Table 1) correlating with the previously reported sequence variant rs219780[T] (r2=0.82, OR=0.81, P=2.6 × 10−11). This evidence concerns the gene CLDN14 and nephrolithiasis.