ALPL and nephrolithiasis: Within ALPL, we also detect a low-frequency missense variant (rs149344982[A], MAF=1.42%, NP_000469.3:p.Arg152His), which associates strongly with reduced serum ALP levels (effect=−45.9 s.d.%, P=9.84 × 10−105) and suggestively with reduced risk of kidney stones (OR=0.742, P=8.1 × 10−3) (Supplementary Table 2).