We observe a genome-wide significant signal with two fully correlated markers associating with kidney stones in ALPL at 1p36.12, represented by rs1256328 [T] (minor allele frequency (MAF)=17.79%, OR=1.21, P=5.8 × 10−10) (Fig. 2; Table 1; Supplementary Table 1). This evidence concerns the gene ALPL and nephrolithiasis.