FBN1 and Marfan syndrome: Further analysis disclosed that 17 of these variants were novel, and only 6 of them were previously reported in MFS, including, p.Arg861×20, 21, p.Cys2307Arg (FBN1 mutations database), p.Asp2329Glu22, p.Met2347delAT23, p.Cys2448Arg24, and p.Gly2536Arg25.