PDE4B and schizophrenia: Subsequently, large population geneticanalyses of schizophrenia have inconsistently implicated single-nucleotidepolymorphisms within PDE4B (Fatemi et al,2008; Guan et al, 2012; Kahler et al, 2010; Numataet al, 2008; Pickard et al,2007; Rastogi et al, 2009;Tomppo et al, 2009).