In summary, the Y358C reduced-function PDE4B mutant resulted in increasedphosphorylation of CREB, decreased binding of PDE4B to DISC1, and upregulation ofDISC1 and β-Arrestin in the hippocampus and amygdala.PDE4BY358C/Y358C mice displayed a phenotype of decreased anxiety,increased exploration, and cognitive enhancement across several tests of learning andmemory, in parallel with hippocampal synaptic changes including enhanced LTP,impaired depotentiation, and enhanced neurogenesis. This evidence concerns the gene DISC1 and Anxiety.