Comparing with the individuals carrying 399Arg/Arg genotype of XRCC1 gene, the subjects with 399Arg/Gln (OR = 1.46, 95 % CI 1.06–2.01) or 399Gln/Gln genotype (OR = 1.93, 95 % CI 1.05–3.54) had a significantly increased risk for CRC. This evidence concerns the gene XRCC1 and colorectal carcinoma.