TP53 and hepatocellular carcinoma: The interaction between the endogenous BAG2 and mutp53 proteins was also observed in several human cancer cell lines, including human colorectal cancer HCT116 p53R248W/−, HT-29 and SW480 cell lines which contain a single copy of Trp53 gene with R248W and R273H mutation, respectively, human breast cancer SK-BR-3, MDA-MB-468 cell lines which contain a single copy of Trp53 gene with R175H and R273H mutation, respectively, and human hepatocellular carcinoma Huh-7 cell lines which contain a single copy of Trp53 gene with Y220C mutation (Figure 2C, Figure 2—figure supplement 1).