Furthermore, the molecule exerts its unique cytotoxic activity with the highest efficacy (EC50 value in the micromolar range) compared to the other molecules tested and this activity was observed for temozolomide-resistant GSCs [23] originating from GBM of three different patients and presenting different molecular signatures (i. e. p53 mutation is observed in TG16 but not in TG1 or OB1 cells). Here, TP53 is linked to glioblastoma.