However, the loss of the genotoxic effect completely neutralised the anti-inflammatory properties of the Nissle strain 1917 in two models of colitis: the Dextran Sodium Sulfate (DSS)-induced colitis in rats and a T-cell dependent model of chronic colitis induced by the adoptive transfer of naive CD4+ CD45RBhigh T cells in immunocompromised SCID mice [94]. This evidence concerns the gene CD4 and colitis.