Similarly, the CSC side population of the SCLC cell line, H1339, detected by the ability to expel Hoechst stain from active ABCG2 transporters, was significantly reduced from 0.75%, following cisplatin treatment alone, to 0.18% when treated with both cisplatin and the Smo inhibitor GDC-0449 [122]. This evidence concerns the gene SMO and small cell lung carcinoma.