FLT3 and acute myeloid leukemia: Mice expressing FLT3-ITD and SmoM2 in the hematopoietic system driven by Mx1-Cre and poly(I:C) treatment produce accumulated populations of c-Kit+Gr-1int and Mac1+Gr1int blasts of the myeloid lineage, leading to myeloproliferative neoplasia (MPN)-AML [109].