Regarding the fibrosis stage, serum hepcidin levels and serum hepcidin/log ferritin ratio were significantly increased in patients with severe fibrosis/cirrhosis compared to patients with none/mild/moderate fibrosis either in the combined group of AIH and PBC/PSC patients [16.6 (19.1) versus 8.4 (7.2); P = 0.017 and 9.7 (11.8) versus 4 (3.8); P = 0.018, respectively] or in AIH patients separately [12.9 (71.8) versus 8.3 (5.2); P = 0.027 and 6.2 (41.05) versus 3.4 (2.19); P = 0.038, respectively], while no association was revealed in PBC/PSC patients. This evidence concerns the gene HAMP and primary biliary cholangitis.