SLC40A1 and Lewy body dementia: However, the broader FC alterations shown in DLB compared with PDD for FPN related seeds may point toward the greater amyloid burden in DLB (Gomperts, 2014) and the network degeneration hypothesis (Seeley et al., 2009), which proposes that different neurodegenerative diseases target specific network systems and in this context previous investigations have suggested a predilection in DLB toward FPN dysfunction (Franciotti et al., 2013; Peraza et al., 2014).