The occurrence of detectable ZO-1 and cingulin labeling, but low or no PLEKHA7 labeling in poorly differentiated ductal carcinomas and in lobular carcinomas, together with the aberrant localization of ZO-1 and cingulin in these tumors, suggests that abortive TJ-like structures can form independently of the formation of a neighbouring PLEKHA7-containing ZA (see also [26, 32]). The gene discussed is TJP1; the disease is breast ductal adenocarcinoma.