BIRC5 and cancer: This was in part because biomedical studies regarding survivin have focused mainly on this gene’s roles in relation to cancer,13,14,23 rather than hPSCs, with the notable exception of one recent paper.15 Therefore, future systematic analyses of candidate m-CRAs, in which viral replication is regulated by promoters of pluripotency-related and/or cancer-specific genes, would not only advance the m-CRA–based antitumorigenic strategy in hPSC-based regenerative medicine, but also help to discover novel aspects of stem cell biology.