Additionally, Ikaros-reconstitution in two IKZF1 deleted Philadelphia positive ALL patients resulted in an upregulation of the B-cell receptor (BCR) signaling pathway and a concomitant cell cycle arrest; showing that in Ph+ ALL pre-B cell receptor signaling suppresses proliferation through an Ikaros-mediated cell cycle arrest [22]. Here, IKZF1 is linked to acute lymphoblastic leukemia.