Several neuroblastoma cell lines revealed 80–90% reduction of MOAP-1-Be(2)c (bone marrow disease derived from SK-N-Be(2)), GoTo (derived from stage IV disease), IMR-32 (derived from the abdominal mass metastatic site), SMS-KAN (KAN, derived from primary pelvic tumor) (Fig. 1E), Nub7 (MycN amplified), and SK-NAS (bone metastasis in origin) (data not shown) when compared with levels in normal human lung primary broncoepithelial (NHBE) cells. Here, MYCN is linked to metastasis.