12, 18). These data reinforce previous findings demonstrating frequent inactivation of RASSF1A and reduced expression of MOAP-1 to result in poor disease outcome (19, 20). Considering that both MOAP-1 and RASSF1A are essential components of death receptor-mediated apoptosis (2, 8), these observations suggest that the reduction of MOAP-1 and RASSF1A expression levels in neuroblastoma cells contributes significantly to poor patient prognosis and decreased survival. This evidence concerns the gene RASSF1 and neuroblastoma.