Moreover, we provide evidence that the transcription factors IKZF1 and IKZF3 repress basal MICA and PVR/CD155 expression in MM cells; our data indicate that silencing of IKZF1 or IKZF3 by shRNA interference (Fig. 3D–3G) or inhibition of their activity by IK6-DN overexpression (Suppl. Here, PVR is linked to Miyoshi myopathy.