In this context, recent papers described the capability of IMiDs to induce CRBN-dependent degradation of the Ikaros family zinc finger protein-1 (IKZF1, Ikaros) and 3 (IKZF3, Aiolos) [34, 35], two transcription factors involved in lymphoid development and differentiation and highly expressed in B cell malignancies, including MM [36, 37]. This evidence concerns the gene IKZF3 and Miyoshi myopathy.