In order to identify possible molecular mediators involved in the upregulation of MICA and PVR/CD155 by IMiDs, we focused our attention on the role of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), recently identified as IMiDs-bound CRBN downstream targets in MM cells [34-36]. Here, CRBN is linked to Miyoshi myopathy.