To better analyse the effects of IMiDs on the expression of NK cell-activating ligands, we initially performed flow cytometric analyses on SKO-007(J3) cells, a MM cell line known to basally express MICA/B and PVR/CD155 [16], after 72h-treatment with micromolar concentrations of lenalidomide or pomalidomide. This evidence concerns the gene MICA and Miyoshi myopathy.