The western blots demonstrated that the canonical NF-κB signaling was constantly activated with increased levels of the phosphorylated IKK-Ser176/180 and IκBα-Ser32/36 proteins, and with reduced protein levels of IκBα in lymphoma in Ndrg2-deficient (Hetero and Homo) as compared with lymphocytes in the peripheral blood of wild-type mice. This evidence concerns the gene NDRG2 and lymphoma.