LDHA overexpression may also promote tumor growth by preventing necrosis in hypoxic environments; Lewis et al noted that tumors created from cell lines overexpressing c‐Myc or c‐Myc target genes LDHA and Rcl were not significantly necrotic compared with tumors from cell lines overexpressing c‐Myc target genes Rcl and VEGF 75. This evidence concerns the gene MYC and neoplasm.