APP/PS1 (APPswe, PSEN1dE9) double transgenic mice are used as a model for Alzheimer's disease and studies showed that 12‐month‐old APP/PS1 mice had decreased PDK1 (pyruvate dehydrogenase kinase isozyme 1), a promoter of aerobic glycolysis, and LDHA expression in their frontal cortex compared with age‐matched controls 90. The gene discussed is PDK1; the disease is early-onset autosomal dominant Alzheimer disease.