BRCA1 and breast carcinoma: Three parallel study designs will test oral PARPi monotherapy vs. physician’s choice single agent chemotherapy in breast cancer patients with PARPi-naive metastatic disease with germline BRCA1/2 mutations: BRAVO (niraparib, NCT01905592 [60]), EMBRACA (talazoparib, NCT01945775 [61]), and OlympiAD (olaparib, NCT02000622 [62]).